PEPTIDES

Generic Peptides

Our Generic Peptides

Leuprorelin, DMF, Ph. Eur, USP, USFDA #25878
Cat #
Introduction Leuprorelin is a synthetic gonadotropin-releasing hormone (GnRH) agonist that binds to GnRH receptors in the anterior pituitary. While initial administration transiently stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), continuous exposure results in receptor desensitization and suppression of gonadotropin secretion. This ultimately reduces the production of sex hormones, including testosterone and estradiol.

Due to its well-characterized mechanism of action, Leuprorelin is widely used in endocrine, reproductive biology, and oncology research. It serves as a valuable tool for investigating hormone-dependent physiological processes, GnRH receptor signaling, and disease models involving hormonal regulation.

This product is supplied with high quality standards to support reliable and reproducible research applications. For Research Use Only (RUO). Not intended for use in diagnostic or therapeutic procedures.
Sequence pGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt
MW 1,209.40 g/mol
Reference 1. Karten MJ, Rivier JE. Gonadotropin-releasing hormone analogs: biology and clinical applications. Endocrine Reviews. 1986;7(1):44–66.
2. Conn PM, Crowley WF Jr. Gonadotropin-releasing hormone and its analogs. New England Journal of Medicine. 1991;324(2):93–103.
3. Andrew V. Schally. Luteinizing hormone-releasing hormone (LHRH) analogs: their impact on the control of hormonal functions and hormone-dependent cancers. Peptides. 1999;20(10):1247–1262.
4. Roger G. Gosden. GnRH analogues in reproductive medicine. Human Reproduction. 2000;15(Suppl 1):25–33.
Fields of application
Synonyms Leuprorelin, Leuprolide, Leuprolide Acetate, Leuprorelin Acetate, Leuprolide Acetate Hydrate, D-Leu⁶, des-Gly-NH₂¹⁰, Pro-NHEt⁹-LHRH, D-Leu⁶-LHRH Ethylamide, [D-Leu⁶, Pro-NHEt⁹]GnRH, [D-Leu⁶, des-Gly-NH₂¹⁰]LHRH Ethylamide, Gonadorelin Analog
Structure
LIST