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Desmopressin, DMF, Ph. Eur, USP
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Introduction Desmopressin is a synthetic analog of arginine vasopressin (AVP) with enhanced antidiuretic activity and high selectivity for the vasopressin V2 receptor. By activating V2 receptors in the renal collecting ducts, desmopressin promotes water reabsorption and has become a valuable tool for investigating mechanisms involved in water homeostasis and renal physiology.

In addition to its renal effects, desmopressin stimulates the release of von Willebrand factor (vWF) and coagulation factor VIII from endothelial cells, making it widely used in studies of hemostasis, vascular biology, and coagulation pathways. Owing to its well-characterized pharmacological profile, desmopressin is extensively utilized in basic and translational research across nephrology, hematology, endocrinology, and pharmacology.
Sequence CYFQNCPRG-NH₂
MW 1069.22 g/mol
Reference 1. Vavra I, Machová A, Holecek V, et al. Effect of a synthetic analogue of vasopressin in animals and in patients with diabetes insipidus. The Lancet. 1968;1(7549):948–952.
2. Mannucci, Pier Mannuccio PM. Desmopressin (DDAVP) in the treatment of bleeding disorders: The first 20 years. Blood. 1997;90(7):2515–2521.
3. Mannucci, Pier Mannuccio PM. How do you treat patients with von Willebrand disease? Blood. 2001;97(7):1915–1919.
4. Robertson, Gary L. GL. Antidiuretic hormone: Normal and disordered function. Endocrinology and Metabolism Clinics of North America. 2001;30(3):671–694.
5. Bichet, Daniel G. DG. Vasopressin receptor antagonists and agonists: Clinical pharmacology and therapeutic applications. Annual Review of Medicine. 2012;63:403–419.
Fields of application
Synonyms Desmopressin, Desmopressin acetate, DDAVP, 1-Deamino-8-D-arginine vasopressin, dDAVP, 1-Deamino-8-D-Arg vasopressin, 1-Deamino-8-D-arginine vasopressin acetate, Deamino-D-arginine vasopressin
Structure
LIST