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Ganirelix, DMF, USFDA #040573
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Introduction Ganirelix is a synthetic decapeptide and a potent gonadotropin-releasing hormone (GnRH) receptor antagonist. By competitively binding to GnRH receptors in the anterior pituitary gland, ganirelix inhibits GnRH-mediated signaling and suppresses the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

Ganirelix is widely used as a valuable research tool for investigating the regulation of the hypothalamic–pituitary–gonadal (HPG) axis, reproductive endocrinology, and GnRH receptor signaling pathways. Its well-characterized antagonistic activity makes it suitable for studies related to hormone regulation, reproductive biology, and peptide pharmacology.
Sequence Ac-DNal-DNal-D-4ClPhe-D-Ser-Ser-Tyr-D-Ser-Leu-Arg-Pro-DAla-NH₂
MW 1570.42 g/mol
Reference 1. DeManno DA, Goetz MA, Ramakrishnan S, et al.
A synthetic decapeptide antagonist of gonadotropin-releasing hormone with improved potency and duration of action.
Endocrinology. 1995;136(4):1921–1930.
2. Fluker MR, Marshall LA, Monroe SE, Jaffe RB.
An antagonist of gonadotropin-releasing hormone (GnRH) in ovarian stimulation for assisted reproductive technology: a randomized controlled trial.
Fertility and Sterility. 2001;75(5):785–791.
3. Huirne JA, Lambalk CB.
Gonadotropin-releasing-hormone-receptor antagonists.
The Lancet. 2001;358(9295):1793–1803.
4. European Society of Human Reproduction and Embryology (ESHRE).
ESHRE guideline: ovarian stimulation for IVF/ICSI.
Human Reproduction Open. 2020.
Fields of application
Synonyms Ganirelix, Ganirelix acetate, Ganirelix acetate hydrate, Antagon, Orgalutran, Org 37462, ORG37462, N-Ac-D-2-naphthylalanyl-D-4-chlorophenylalanyl-D-3-(2-naphthyl)alanyl-D-seryl-D-seryl-tyrosyl-D-seryl-leucyl-arginyl-prolyl-D-alaninamide, GnRH antagonist, Gonadotropin-releasing hormone antagonist
Structure
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