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Vasopressin, DMF, US FDA submission in 3Q 2026
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Introduction Vasopressin, also known as arginine vasopressin (AVP) or antidiuretic hormone (ADH), is a naturally occurring nonapeptide hormone that plays a critical role in regulating water homeostasis, vascular tone, and endocrine function. Vasopressin exerts its biological effects through activation of three G protein-coupled receptors (GPCRs): V1a, V1b, and V2 receptors.

Activation of V2 receptors in the renal collecting ducts promotes water reabsorption by regulating aquaporin-2 (AQP2) trafficking, while V1a and V1b receptor signaling contributes to vascular regulation and neuroendocrine responses. Due to its well-characterized receptor activity and physiological functions, vasopressin is widely used as a research tool in studies of renal physiology, cardiovascular biology, neuroendocrinology, and GPCR signaling pathways.
Sequence CYFQNCPRG-NH₂
MW 1084.23 g/mol
Reference 1. du Vigneaud V, Gish DT, Katsoyannis PG.
A synthetic preparation possessing biological properties associated with arginine vasopressin.
Journal of the American Chemical Society. 1954;76(18):4751–4752.
2. Bankir L, Bichet DG, Morgenthaler NG.
Vasopressin: physiology, assessment and osmosensation.
Journal of Internal Medicine. 2017;282(4):284–297.
3. Treschan TA, Peters J.
The vasopressin system: physiology and clinical strategies.
Anesthesia & Analgesia. 2006;102(4):1246–1255.
4. Barberis C, Mouillac B, Durroux T.
Structural bases of vasopressin/oxytocin receptor function.
Journal of Endocrinology. 1998;156(2):223–229.
5. Thibonnier M, Coles P, Thibonnier A, Shoham M.
The basic and clinical pharmacology of vasopressin receptors.
Vitamins and Hormones. 2001;63:101–165.
Fields of application
Synonyms Vasopressin, Arginine vasopressin, AVP, Antidiuretic hormone, ADH, 8-L-Arginine vasopressin, L-Arginine vasopressin, Pitressin, 8-Arginine vasopressin, Argipressin, [Arg8]-Vasopressin, Human arginine vasopressin
Structure
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